Presentations in this session:

12:35 WePp0102    Abstract The L74V mutation in HIV-1 RT impairs unblocking of ZDV-terminated DNA primers and reduces synthesis of viral DNA in real-time PCR Frankel F.1, Marchand B.1, Götte M.1, Wainberg M.A.1 1McGill University AIDS Centre, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada

12:40 WePp0103    Abstract Binding energetics analysis shows a unique response of tipranavir to HIV-1 protease mutations associated with drug resistance Muzammil S.1, Kang L.-W.2, Armstrong A.A.2, Jakalian A.3, Bonneau P.R.3, Schmelmer V.4, Amzel L.M.2, Freire E.1 1Department of Biology, Johns Hopkins University, Baltimore, MD, United States of America, 2Department of Biophysics and Biophysical Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD, United States of America, 3Boehringer Ingelheim (Canada) Ltd. Research & Development, Laval, Québec, Canada, 4Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT, United States of America

12:45 WePp0104    Abstract Multivalent compounds functionalized with the carbohydrate headgroups of immune cell-surface GSLs as inhibitors of HIV-1 infection. Rosa Borges A.1, Puri A.2, Krebs F.C.3, Wigdahl B.3, Blumenthal R.2, Rawat S.S.2, Johnson B.T.2, Schengrund C.-L.1 1Penn State University, College of Medicine, Hershey, Pennsylvania, United States of America, 2Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America, 3Drexel University, College of Medicine, Philadelphia, Pennsylvania, United States of America

12:50 WePp0105    Abstract Crystallographic study with BILR 355 BS, a novel non-nucleoside reverse transcriptase inhibitor (NNRTI) with a broad anti HIV-1 profile Coulombe R.1, Fink D.1, Landry S.1, Lessard I.A.D.1, McCollum R.1, Naud J.1, O'Meara J.1, Simoneau B.1, Yoakim C.1, Bonneau P.R.1 1Boehringer Ingelheim (Canada) Ltd, Laval, Canada

12:55 WePp0106    Abstract Novel compounds that inhibit HIV replication by acting through inhibition of HIV rev function Rekosh D.1, Ptak R.2, Hammarskjold M.-L.1 1University of Virginia, Department of Microbiology, Charlottesville, VA, United States of America, 2Southern Research Institue, Department of Infectious Disease Research, Frederick, MD, United States of America